Genomics Postdoctoral Fellow (ref. PD/21/03)

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IRB Barcelona is seeking a motivated Genomics Postdoctoral Fellow to work on the project entitled “Improved Clinical Decisions Via Integrating Multiple Data Levels to Overcome Chemotherapy Resistance In High-Grade Serous Ovarian Cancer (DECIDER)”, funded by the European Union’s Horizon 2020 research and innovation programme (propsal No 965193).   

DECIDER is an international consortium consisting of 14 academic labs and 4 companies spread across 7 EU countries and coordinated by University of Helsinki.  The project has a strong translational component, aiming to bringing actionable insight to the clinic to improve treatment of recurrent, drug-resistant ovarian cancer and improve patient outcomes.

The role of the Genome Data Lab of the IRB in the DECIDER project is to chart tumor evolution via large-scale chromosomal alterations: we will examine how driver mutations that confer fitness benefits (aggressive growth and/or drug resistance) change through time, with the aim of being able to anticipate cancer evolution.

The genomics postdoctoral fellow will address the following objectives:

(i) deriving statistical models to predict frequency of genomic alterations occurring in late-stage, genomically unstable and/or pretreated cancers

(ii) implementing a statistical framework to estimate fitness effects of various classes of genomic alterations (such as indels or translocations or related), with focus on drug resistance mutations.

(iii) performing statistical analyses that associate the co-occurrence of various classes of mutations at the same genomic locus e.g. point mutations with indels, or related (“complex events”)

The research will be performed in the Genome Data Science lab (https://agendas.irbbarcelona.org/), under supervision of ICREA Professor and EMBO YIP Fran Supek, and in collaboration with the diverse, international team in the lab, which consists of genomics biologists, wet-lab biologists and mathematicians at the PhD and postdoc level.

Additionally, the genomics postdoctoral fellow may collaborate with other project partners (in Finland, Italy, France, Germany, Denmark or Sweden) to boost the quality of the work above e.g. by incorporating network analysis, RNA-Seq analysis, and histology image analysis.

 

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Start date is flexible; spring 2021 is preferable. Early applications are encouraged. Informal enquires can be directed to the PI at fran.supek@irbbarcelona.org

 

Relevant publications:

 

Lindeboom, Vermeulen, Lehner and Supek (2019) Nature GeneticsThe impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

Mas-Ponte and Supek (2020) Nature Genetics, “DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

Salvadores, Fuster and Supek (2020) Science Advances, “Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns

Supek and Lehner. (2017) Cell.Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes

Supek et al. (2014) Cell.Synonymous mutations frequently act as driver mutations in human cancers

 

DUTIES: 

  • Perform excellent research according to the high standards of the Supek lab and the IRB Barcelona
  • Publish results in top-tier computational biology and/or genetics journals
  • Present at weekly lab meetings and journal clubs, at department seminars, and conferences
  • Engage in teamwork with other members of the host lab to facilitate progress on the project
  • Participate in the DECIDER project activities: meetings, presentations, visits to other labs, collaboration, exchange of data sets, preparing project reports/deliverables.

EXPERIENCE, KNOWLEDGE, SKILLS:

Must Have – Required: 

  • Experience: PhD in the natural sciences or mathematics.  Some experience with genomic or transcriptomic data analysis.
  • Skills: highly motivated, with enthusiasm to work on challenging topics in genomics. Intermediate-to-advanced knowledge of one programming language.

Desirable:

  • Experience: Experience with human population genomics or inherited disease genomics or cancer genomics.  Experience with developing statistical methodologies for genomic analysis.
  • Skills: independent, self-learning, goal-oriented. Solid level of spoken English.


WORKING CONDITIONS & ENTITLEMENTS:

  • Working conditions: Employed in compliance with Spanish legislation and regulations under a full-time contract. Employees receive the benefits of the Spanish Social Security system covering sickness, maternity/paternity leaves and injuries at work.
  • Training and Career: Postdoctoral researchers joining IRB Barcelona gain access to the Institute’s advanced research training and career development opportunities, all within in a competitive international environment. Courses and workshops on themes of particular interest to postdocs are offered regularly by the Institute.
  • International environment: Nearly 90 Postdoctoral researchers (more than a half non-Spanish nationals) are currently working at IRB Barcelona.

 

HOW TO APPLY & SELECTION PROCESS:

  • Deadline for applications: 21/02/2021 (If no suitable candidate is found, the deadline will be extended) 
  • Number of positions available: 1
  • Selection process:
    • Pre-selection: Will be based on CV, motivation letter, experience, management of research and innovation. 
    • Interviews: Short-listed candidates will be interviewed.
    • Job offer: Will be sent to the successful candidate after the interview. 


Note: The strengths and weaknesses of the applications will be provided upon request.

'If you, as an applicant, have any suggestion or wish to make a complaint regarding the selection process, please contact us at the following email address: irbrecruitment.suggestions@irbbarcelona.org You will receive a response within a month.'



 

Or, know someone who would be a perfect fit? Let them know!

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